Barthwal Manoj PhD
Field of Expertise
Division of Pharmacology CSIR-Central Drug Research Institute Lucknow-226 031, UP
Dr. Manoj Kumar Barthwal is a senior scientist at the Division of Pharmacology, CDRI, Lucknow, India. He did his Ph.D in Biochemistry from Lucknow University in 2001. He has over fifteen years of rich experience in the area of cellular signaling and cardiovascular pharmacology. He has worked for more than six years in the in the area of cardiovascular research at the Experimental Atherosclerosis Section, National Heart Lung and Blood Institute, NIH, Bethesda and the Division of Molecular Cardiology, Cardiovascular Research Institute, Texas A&M-Health Science Center, Texas. Presently Dr. Barthwal’s group is involved in understanding the molecular mechanism of cardiometabolic disorders like atherosclerosis and the role of inflammation, innate immunity and hyperlipidemia in the same. Dr Barthwal’s laboratory is investigating role of macrophages and vascular smooth muscle cells in the progression of cardiometabolic disorders like atherosclerosis. Protein Kinase mediated signaling and phosphorylation events are of special interest. Final aim is to contribute in the identification and development of therapeutic targets for atherosclerosis treatment. At the same time research group is also involved in the development of in vivo and in vitro models of atherothrombosis for understanding the disease mechanism and screening CDRI lead molecules for their anti-atherothrombotic effect. Novel anti-atherothrombotic molecules have been characterized in animal models of atherosclerosis developed by Dr Barthwal’s group.
Studies have demonstrated anti-atherosclerotic and anti-inflammatory effects of curcuma derived formulations by novel mechanisms. Recent research from Dr Barthwal’s laboratory demonstrates the role of Interleukin 1 Receptor Associated Kinase (IRAK) in IL-1β production in the monocytic cells. This study proposes new therapeutic targets for the prevention of chronic inflammatory diseases involving IL-1β production. Research findings also demonstrated role of native and modified LDL in macrophage foam cell formation that was mediated by PI3K and IRAK pathway respectively. Studies in vascular smooth muscle cells and rat model of atherosclerosis demonstrated role of IRAK in smooth muscle proliferation and neo-intimal hyperplasia. Dr. Barthwal’s research work is published in international peer reviewed and leading journals of the area. Dr. Barthwal has received funding from the DST, DBT and ICMR India. Dr. Barthwal has received awards from International Atherosclerosis Society and Indo-US Science and Technology Forum India for carrying out his research work. He is life member of The Cytometry Society, India, Indian Society For Atherosclerosis Research, The National Academy of Sciences, India and International Atherosclerosis Society.