Chakraborti Sajal

Chakraborti Sajal PhD, DSc

Professor of Biochemistry & Head, Dept of Biochemistry and Biophysics

Field of Expertise
Biochemistry & Biophysics
Department of Biochemistry & Biophysics, University of Kalyani, Kalyani 741235, West Bengal

Prof. Sajal Chakraborti received his MSc (1976) and PhD (1982) degrees in Biochemistry from the University of Calcutta and DSc (2004) degree in Biochemistry from the University of Kalyani, West Bengal. He received Fulbright Fellowship for post doctoral research at the Johns Hopkins University, University of Utah and also at the New York Medical College (1987-1990). He joined the University of Kalyani as a Lecturer in 1985 and in 2006; he became Professor of Biochemistry at the same University. He also received DBT (senior) overseas fellowship in the year 1999 for his research at the University of Florida (Gainesville). His research for the past thirty years aimed at understanding basic biochemical mechanisms that regulate pulmonary vascular tone. His research contributed significantly in the field of proteases like matrix metalloproteases, serine proteases and calpain and their role in the activation of phospholipase A2 to generate the powerful vasoactive mediator, thromboxanes.

His research on mitochondrial mu-calpain received recognition internationally as his team first described the presence of mu-calpain and its endogeneous inhibitor, calpatatin in mitochondrial compartments, and their role in apoptosis during stimulation by intracellular Ca2+ mobilizing agonists. Additionally, his team elucidated the underlying mechanism of why post treatment of a dilator cannot overcome the effect of a constrictor in pulmonary vasculature. His team published more than one hundred research articles, reviews, and book chapters in internationally standing journals such as Biochemistry (USA), Biochim Biophys Acta, Cellular Signalling, Biochemical Journal, Archives of Biochemistry and Biophysics, IUBMB Life, American Journal of Physiology, FEBS Letters, Biochimie, Life Sciences and European Journal of Biochemistry. He also edited four books on proteases and ATPases, which have already been published by Springer (New York).