Natesan Sankar Ph.D
Field of Expertise
Department of Genetic Engineering School of Biotechnology Madurai Kamaraj University Madurai-625021, Tamil Nadu
Dr Sankar Natesan has joined as a direct Professor in the Department of Genetic Engineering, School of Biotechnology, Madurai Kamaraj University in 2014. He completed his PhD program in the Department of Biochemistry, School of Biological Sciences, Madurai Kamaraj University in the year 2000 on Molecular Cardiology. Later he had professional training in National Cancer Center, Singapore followed by Northwestern University, Loyola University of Chicago and Texas Tech University, Lubbock in USA. His current research interest is to elucidate the role of inositol 1,4,5-triphosphate receptors, a family of ligand operated Ca2+ channels in hypertrophic cardiomyopathy (HCM).
At present his laboratory is focusing on the regulation of Ca2+-calmodulin kinase II delta (CaMKII) signaling pathways by InsP3R2 and its contribution in HCM. Importantly his group is working on intervention of InsP3R2 Ca2+ channel activity by "competitive inhibition" and "blocking inhibition" using peptides and antibodies respectively, as a novel therapeutic molecules to inhibit the development of cellular/cardiac hypertrophy using Adult Cardiomyocytes and animal models. Recently he has been nominated as a member, Monitoring and Evaluation Committee, ICMR-MRDU project to Theni Medical Colleage, Theni, Tamilnadu.