Srinivas Gopala

Srinivas Gopala PhD

Finance Secretary

Acting Head, Department of Biochemistry

Field of Expertise
Basic Cardiology
Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum

Dr. Srinivas Gopala is currently the Acting Head, Department of Biochemistry, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, where he is working from June 2004. Currently he runs several joint studies with clinicians to pursue and solve research questions of mutual interest that includes studies involving mitochondrial metabolism and function in diabetic heart, role of cardiac autophagy in controlling mitochondrial function under hyperglycemic stress and in offsprings of gestational diabetic models and impact of nitrates in cardiac and muscle mitochondrial function. In 2009, he was awarded the IndoUS Scientific Research Fellowship to work at the Division of Endocrinology, Diabetes, Metabolism and Nutrition Mayo Clinic, USA to work on skeletal muscle mitochondrial alterations and protein modifications during diabetes.
Apart from these, inflamosome pathway in Alzheimer’s disease patient macrophages and pathways leading to activation of MTH1 in glioma are other work done in his laboratory.

Currently, 7 students are pursuing PhD in his lab and 4 were awarded PhD in the past.As a trained cancer researcher, he has been working in the area of clinical and experimental oncology for more than 20 years and has published several papers on antiproliferative, anti angiogenic and metastasis inhibitory actions of natural products like emodin, plumbagin, allicin, nimbolide, aloe emodin and synthetic molecules like benzoxanthone lignans in a variety of tumor cells.
He received the ICMR International Research Fellowship in 2014 to pursue his research interests again in Mayo Clinic, USA to initiate a work on brain mitochondrial function in type 1 diabetic mice. He is a life member of several professional bodies such as Society for Biotechnologists (India), International Society for Heart Research (India Section), Society for Mitochondrial Research & Medicine, India and a professional member of American Diabetes Association.